Anti-CD112/Nectin-2/PVRL2 antibody

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  • 抗体类型:单克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, WB, IP
  • 特异性:Mouse PVRL2 / CD112 / Nectin-2
    No cross-reactivity in ELISA with Human CD112 / Nectin-2

产品详情

  • 产品名称
    Anti-CD112/Nectin-2/PVRL2 antibody
  • 抗体类型
    单克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Rabbit monoclonal to CD112/Nectin-2/PVRL2
  • 抗体应用
    ELISA, WB, IP
  • 应用推荐

    WB: 20-50 μg/ml

    ELISA: 0.5-1 μg/mL

    This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Mouse PVRL2. The detection limit for Mouse PVRL2 is 0.00245 ng/well.

    IP: 1-4 μg/mg of lysate

  • 特异性
    Mouse PVRL2 / CD112 / Nectin-2
    No cross-reactivity in ELISA with Human CD112 / Nectin-2
  • 蛋白别名
    nectin-2, nectin-2, PRR2, PRR2, Pvrl2, PVRL2, PVRR2, HVEB, PRR2, CD112, PVRR2, MPH, Pvr, Cd112, AI325026, AI987993, nectin-2, PVS, Pvr, PVS, AI325026, AI987993, CD112, CD112, HVEB, mHVEB, MPH
  • 制备方法
    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PVRL2 extracellular domain (rM PVRL2; NP_033016.3; Met 1-Gly 351).
  • 组分
    0.2 μm filtered solution in PBS with 5% trehalose
  • 储存方法
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • 背景介绍
    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
  • 参考文献
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