重组人PLAU蛋白

产品详情

  • 产品名称
    重组人PLAU蛋白
  • 蛋白种属
    人
  • 表达宿主
    人胚胎肾细胞（HEK293）
  • Unitprot ID
    P00749
  • 克隆构建
    A DNA sequence encoding the Human PLAU Ser21-Leu431 is expressed with a 6His tag at the C-terminus.
  • 蛋白纯度
    >95% as determined by SDS-PAGE.
  • 蛋白全名
    plasminogen activator, urokinase(PLAU)
  • 蛋白描述
    Recombinant Human Urokinase-Type Plasminogen Activator is a serine protease, which specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Human Urokinase-Type Plasminogen Activator is initially synthesized as 431 amino acid precursor with a N-terminal signal peptide residues. The single chain molecule is processed into a disulfide-linked two-chain molecule. There exists two forms A chain, the long A chain contains an EGF-like domain that is responsible for binding of the uPA receptor. The B chain corresponds to the catalytic domain.
  • 发货形式
    Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 2mM CaCl, 10% Glycerol, pH 7.5.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Store at <-20°C, minimize freeze-thaw cycles.
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