- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:WB
- 特异性:Human, Mouse, Rat
SPPL2A Polyclonal Antibody
产品详情
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产品名称
SPPL2A Polyclonal Antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Polyclonal antibody to SPPL2A
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抗体应用
WB
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应用推荐
WB 1:200 - 1:2000
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特异性
Human, Mouse, Rat
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蛋白别名
SPPL2A, IMP3, PSL2, signal peptide peptidase-like 2A
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制备方法
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 421-520 of human SPPL2A (NP_116191.2).
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组分
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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储存方法
Store at -20℃. Avoid freeze / thaw cycles.
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背景介绍
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.
相关服务
抗体定制服务: 纽普生物（NovoPro）提供单克隆抗体及多克隆抗体定制服务