重组人IL27RA蛋白

人

人胚胎肾细胞（HEK293）

A DNA sequence encoding the Human IL27RA/CRL1/TCCR/WSX1/UNQ296 Gly34-Lys516 is expressed with a Fc tag at the C-terminus.

>90% as determined by SDS-PAGE.

CRL1; TCCR; WSX1; UNQ296; PRO336

interleukin 27 receptor subunit alpha(IL27RA)

Interleukin-27 receptor alpha is also known as WSX 1, TCCR and IL 27 R alpha. IL-27 R alpha belongs to the typeⅠ,group 2 cytokine receptor family . Mature IL 27 R alpha is a type I transmembrane glycoprotein which is consist of a 484 amino acid aa extracellular region, a 21 aa transmembrane segment and a 99 aa cytoplasmic domain. Human IL-27 R alpha extracellular region show 63% aa sequence identity with those of mouse IL 27 R alpha extracellular domain. It is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. The function of human IL-27 R alpha is to act as the receptor of human IL-27 and to involve in the regulation of Th1-type immune responses. In addition, IL‑27 R alpha is reported to complex with CNTFR alpha and gp130 form a human in receptor on neurons, and to complex with gp130 and IL‑6 R to form a receptor for a p28:CLF heterodimeric cytokine on lymphocytes.

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

<1.0 EU per μg protein as determined by the LAL method.

Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.