MAF antibody

多克隆

兔

兔IgG

MAF Rabbit Polyclonal antibody. Positive IP detected in A431 cells. Positive WB detected in A431 cells, A375 cells, K-562 cells. Positive IF detected in A431 cells. Positive IHC detected in human kidney tissue. Observed molecular weight by Western-blot: 48-50 kDa

ELISA, IHC, WB, IP, IF

Human,Mouse,Rat; other species not tested.

c MAF, cMAF, MAF, Proto oncogene c Maf, Transcription factor Maf

This antibody was obtained by immunization of Peptide (Accession Number: NM_005360). Purification method: Antigen affinity purified.

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MAF, also named as c-Maf, belongs to the bZIP family and Maf subfamily. MAF acts as a transcriptional activator or repressor. It is involved in embryonic lens fiber cell development. MAF increases T cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, it transactivates strongly the glucagon gene promoter through the G1 element. MAF activates transcription of the CD13 proximal promoter in endothelial cells. It is involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. When overexpressed, MAF represses anti-oxidant reponse element (ARE)-mediated transcription. It is involved either as an oncogene or as a tumor suppressor, depending on the cell context. A chromosomal aberration involving MAF is found in some forms of multiple myeloma (MM). Defects in MAF are the cause of cataract pulverulent juvenile-onset MAF-related (CAPJOM). Defects in MAF are the cause of cataract congenital cerulean type 4 (CCA4). The antibody is specific to MAF.