OTX2 antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:ELISA, WB, IHC, FC, IP
  • 特异性:Human,Mouse,Rat; other species not tested.

产品详情

  • 产品名称
    OTX2 antibody
  • 抗体类型
    多克隆
  • 抗体来源
  • 抗体亚型
    兔IgG
  • 抗体描述
    OTX2 Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue. Positive FC detected in hESC cells. Positive IP detected in Y79 cells. Positive WB detected in Y79 cells. Observed molecular weight by Western-blot: 32kd
  • 抗体应用
    ELISA, WB, IHC, FC, IP
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:500-1:5000

    IHC: 1:20-1:200

  • 特异性
    Human,Mouse,Rat; other species not tested.
  • 蛋白别名
    Homeobox protein OTX2, MCOPS5, orthodenticle homeobox 2, Orthodenticle homolog 2, OTX2
  • 制备方法
    This antibody was obtained by immunization of OTX2 recombinant protein (Accession Number: NM_021728). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    The orthodenticle homeobox 2, encoded by OTX2 gene, is a key transcription factor in developmental processes. In particular, it is required for the early specification of the brain and the embryonic development of sensory organs, including the, pineal gland, pituitary gland, inner part of the ear, eyes, and optic nerve. In later stages, it is important for maintaining intact retina and brain function. In addition, it acts as a transcriptional repressor and a gatekeeper of myogenic and neuronal differentiation in medulloblastoma cells. OTX2 binds to the MyoD1 core enhancer through its homeobox domain and the remarkable repressor activity exhibited by the homeobox domain renders OTX2 transcriptionally repressive
  • 参考文献
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