- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:Human; other species not tested.
产品详情
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产品名称
AIM2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
AIM2 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, A549 cells, COLO 320 cells, HeLa cells, HepG2 cells, Jurkat cells, MCF7 cells, SH-SY5Y cells. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 40-45kd
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抗体应用
ELISA, WB, IHC
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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特异性
Human; other species not tested.
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蛋白别名
absent in melanoma 2, AIM2, PYHIN4
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制备方法
This antibody was obtained by immunization of AIM2 recombinant protein (Accession Number: BC010940). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria [PMID: 22695634]. Upon binding to DNA, it is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Otherwise, it functions as a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity [PMID:16432157,20566831].
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参考文献
- Wu DL, Xu GH, Lu SM. Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B. Human immunology. 74(5):514-21. 2013.