AIM2 antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:ELISA, WB, IHC
  • 特异性:Human; other species not tested.

产品详情

  • 产品名称
    AIM2 antibody
  • 抗体类型
    多克隆
  • 抗体来源
  • 抗体亚型
    兔IgG
  • 抗体描述
    AIM2 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, A549 cells, COLO 320 cells, HeLa cells, HepG2 cells, Jurkat cells, MCF7 cells, SH-SY5Y cells. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 40-45kd
  • 抗体应用
    ELISA, WB, IHC
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • 特异性
    Human; other species not tested.
  • 蛋白别名
    absent in melanoma 2, AIM2, PYHIN4
  • 制备方法
    This antibody was obtained by immunization of AIM2 recombinant protein (Accession Number: BC010940). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria [PMID: 22695634]. Upon binding to DNA, it is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Otherwise, it functions as a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity [PMID:16432157,20566831].
  • 参考文献
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