- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
-
产品名称
ALDH2 antibody
-
抗体类型
多克隆
-
抗体来源
兔
-
抗体亚型
兔IgG
-
抗体描述
ALDH2 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue, human heart tissue. Positive IP detected in mouse lung tissue. Positive WB detected in mouse lung tissue, human heart tissue, human kidney tissue, human liver tissue, MCF7 cells, mouse skeletal muscle tissue, rat lung tissue. Observed molecular weight by Western-blot: 50-55 kDa
-
抗体应用
ELISA, WB, IHC, IP
-
应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:500-1:5000
IHC: 1:20-1:200
-
特异性
Human,Mouse,Rat; other species not tested.
-
蛋白别名
ALDH class 2, ALDH E2, ALDH2, ALDHI, ALDM
-
制备方法
This antibody was obtained by immunization of ALDH2 recombinant protein (Accession Number: NM_000690). Purification method: Antigen affinity purified.
-
组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
储存方法
Store at -20℃. DO NOT ALIQUOT
-
背景介绍
Acetaldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. It mediates NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol. Thus, the absence of this enzyme is linked to alcohol intolerance and a reduced risk for alcoholism-related liver disease.
-
参考文献
- Amanuma Y, Ohashi S, Itatani Y. Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium. Scientific reports. 5:14142. 2015.
- Oberbeck N, Langevin F, King G, de Wind N, Crossan GP, Patel KJ. Maternal aldehyde elimination during pregnancy preserves the fetal genome. Molecular cell. 55(6):807-17. 2014.
- Ying Q, Ansong E, Diamond AM, Lu Z, Yang W, Bie X. Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways. PloS one. 10(5):e0126285. 2015.
- Liu H, Zhang H, Cui R, Guo X, Wang D, Dai J. Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver. Archives of toxicology. 2015.