Amyloid beta (A4) precursor protein antibody

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  • 抗体类型:单克隆
  • 抗体来源:小鼠
  • 抗体应用:ELISA, WB, IHC
  • 特异性:Human, Pig; other species not tested.

产品详情

  • 产品名称
    Amyloid beta (A4) precursor protein antibody
  • 抗体类型
    单克隆
  • 抗体来源
    小鼠
  • 抗体亚型
    小鼠IgG2a
  • 抗体描述
    Amyloid beta (A4) precursor protein Mouse Monoclonal antibody. Positive IHC detected in human gliomas tissue. Positive WB detected in Y79 cells, HEK-293 cells. Observed molecular weight by Western-blot: 100 kDa
  • 抗体应用
    ELISA, WB, IHC
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • 特异性
    Human, Pig; other species not tested.
  • 蛋白别名
    AAA, ABETA, ABPP, AD1, AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP beta
  • 制备方法
    This antibody was obtained by immunization of Amyloid beta (A4) precursor protein recombinant protein (Accession Number: BC004369). Purification method: Protein A purified.
  • 组分
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).
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