- 抗体类型:单克隆
- 抗体来源:小鼠
- 抗体应用:ICC/IF, WB, IHC-P
- 特异性:Human, Mouse, Rat, Chicken
产品详情
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产品名称
Anti-Bcl-2 (3H5) Mouse antibody
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抗体类型
单克隆
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抗体来源
小鼠
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抗体亚型
小鼠IgG1
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抗体描述
Bcl-2 (3H5) Mouse monoclonal antibody
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抗体应用
ICC/IF, WB, IHC-P
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应用推荐
IF: 1/50-200
WB: 1/1000-2000
IHC: 1/200
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特异性
Human, Mouse, Rat, Chicken
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制备方法
Antigen: Synthetic Peptide of Bcl-2
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组分
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
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储存方法
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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背景介绍
Swiss-Prot Acc.P10415.Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
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参考文献
- Aqueous extract of Fritillariae cirrhosae induces cellular apoptosis through activation of STATs-mediated immunomodulation