- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:WB, ICC/IF, FC, IP
- 特异性:Human, Mouse, Rat
产品详情
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产品名称
Anti-Cdk4 Rabbit antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Cdk4 Rabbit polyclonal antibody
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抗体应用
WB, ICC/IF, FC, IP
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应用推荐
WB: 1/1000
ICC/IF: 1/50
FC: 1/20
IP: 1/20
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特异性
Human, Mouse, Rat
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蛋白别名
CMM3; PSK-J3
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制备方法
Antigen: A synthetic peptide of human Cdk4
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组分
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存方法
Store at -20°C. Stable for 12 months from date of receipt.
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背景介绍
Swiss-Prot Acc.P11802.Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.