- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:WB, IHC-P, ICC/IF, FC, IP
- 特异性:Human, Mouse, Rat
产品详情
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产品名称
Anti-CTNNA1 Rabbit antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
CTNNA1 Rabbit polyclonal antibody
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抗体应用
WB, IHC-P, ICC/IF, FC, IP
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应用推荐
WB: 1/5000
IHC: 1/20
ICC/IF: 1/50
FC: 1/20
IP: 1/20
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特异性
Human, Mouse, Rat
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蛋白别名
MDPT2; CAP102
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制备方法
Antigen: A synthetic peptide of human alpha 1 Catenin
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组分
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存方法
Store at -20°C. Stable for 12 months from date of receipt.
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背景介绍
Swiss-Prot Acc.P35221.Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.