Anti-CXCL12 / SDF-1 beta antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:IHC-P
  • 特异性:Human CXCL12 / SDF-1 beta


  • 产品名称
    Anti-CXCL12 / SDF-1 beta antibody
  • 抗体类型
  • 抗体来源
  • 抗体亚型
  • 抗体描述
    Rabbit polyclonal to CXCL12 / SDF-1 beta
  • 抗体应用
  • 应用推荐

    IHC-P: 0.1-2 μg/ml

  • 特异性
    Human CXCL12 / SDF-1 beta
  • 蛋白别名
    AI174028, chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1), Cxcl12, CXCL12, PBSF, Pbsf, Scyb12, SCYB12, Sdf1, SDF1, Sdf1a, SDF1A, SDF-1a, Sdf1b, SDF1B, SDF-1b, Tlsf, Tlsfa, TLSF-a, Tlsfb, TLSF-b, Tpar1, TPAR1, IRH, PBSF, SDF1, TLSF, TPAR1, SCYB12, Pbsf, Sdf1, Tlsf, Tpar1, Scyb12
  • 制备方法
    Produced in rabbits immunized with purified, recombinant Human CXCL12 / SDF-1 beta (rh CXCL12 / SDF-1 beta; P48061-1; Lys22-Met93). CXCL12 / SDF-1 beta specific IgG was purified by Human CXCL12 / SDF-1 beta affinity chromatography.
  • 组分
    0.2 μm filtered solution in PBS
  • 储存方法
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • 背景介绍
    The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. CXCL12 and CXCR4 that have been widely characterized in peripheral tissues and delineate their main functions in the CNS. Extensive evidence supports CXCL12 as a key regulator for early development of the CNS. In the mature CNS, CXCL12 modulates neurotransmission, neurotoxicity and neuroglial interactions. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism. Although considered an important factor in normal bone metabolism, recent studies implicate CXCL12 in the pathogenesis of several diseases involving the skeleton, including rheumatoid arthritis and cancers that metastasize to bone. The CXCL12/CXCR4 axis is involved in tumor progression, angiogenesis, metastasis, and survival. Pathologically enhanced CXCL12 signaling may promote the formation of new vessels through recruiting circulating endothelial progenitor cells or directly enhancing the migration/growth of endothelial cells. Therefore, CXCL12 signaling represents an important mechanism that regulates brain tumor angiogenesis/vasculogenesis and may provide potential targets for anti-angiogenic therapy in malignant gliomas.
  • 参考文献
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