Anti-IL-6 antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, IHC-P
  • 特异性:Cynomolgus IL6 / Interleukin-6

产品详情

  • 产品名称
    Anti-IL-6 antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Rabbit polyclonal to IL-6
  • 抗体应用
    ELISA, IHC-P
  • 应用推荐

    ELISA: 0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Cynomolgus IL6 / Interleukin-6. The detection limit for Cynomolgus IL6 / Interleukin-6 is approximately < 0.039 ng/well.

    IHC-P: 0.1-1 μg/mL

  • 特异性
    Cynomolgus IL6 / Interleukin-6
  • 蛋白别名
    HGF, HSF, BSF2, IL-6, IFNB2, Il-6, BSF2, HGF, HSF, IFNB2, IL6, IL-6
  • 制备方法
    Produced in rabbits immunized with purified, recombinant Cynomolgus IL6 / Interleukin-6 (Pro29-Met212). IL6 / Interleukin-6 specific IgG was purified by Cynomolgus IL6 / Interleukin-6 affinity chromatography.
  • 组分
    0.2 μm filtered solution in PBS with 5% trehalose
  • 储存方法
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • 背景介绍
    Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
  • 参考文献
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