- 抗体类型:单克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC-P
- 特异性:Human IL20RA / IL-20RA
No cross-reactivity in ELISA with Human IFNgR1; Human IL10RB
产品详情
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产品名称
Anti-IL20RA/IL-20RA antibody
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抗体类型
单克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Rabbit monoclonal to IL20RA/IL-20RA
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抗体应用
ELISA, IHC-P
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应用推荐
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IL20Ra.
IHC-P: 1-10 μg/mL
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特异性
Human IL20RA / IL-20RA
No cross-reactivity in ELISA with Human IFNgR1; Human IL10RB -
蛋白别名
E230031K19, FLJ40993, IL-20R1, Il20ra, IL20RA, RP11-204P2.1, ZCYTOR7, CRF2-8, IL-20R1, IL-20RA, IL-20R-alpha, E230031K19
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制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human IL20RA / IL-20RA (rh IL20RA / IL-20RA; NP_055247.21; Met 1-Lys 250).
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组分
0.2 μm filtered solution in PBS with 5% trehalose
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储存方法
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
背景介绍
Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes.
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参考文献
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