- 抗体类型:单克隆
- 抗体来源:兔
- 抗体应用:WB, IHC-P, ICC/IF, FC, IP
- 特异性:Human, Mouse
产品详情
-
产品名称
Anti-ILF3/NF90 Rabbit antibody
-
抗体类型
单克隆
-
抗体来源
兔
-
抗体亚型
兔IgG
-
抗体描述
ILF3/NF90 Rabbit monoclonal antibody
-
抗体应用
WB, IHC-P, ICC/IF, FC, IP
-
应用推荐
WB: 1/2000-1/20000
IHC: 1/50
ICC/IF: 1/100
FC: 1/20
IP: 1/20
-
特异性
Human, Mouse
-
蛋白别名
CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; TCP110; MPHOSPH4; NF-AT-90
-
制备方法
Antigen: A synthetic peptide of human ILF3
-
组分
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
-
储存方法
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
-
背景介绍
Swiss-Prot Acc.Q12906.RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).