Anti-Integrin alpha 5 Rabbit antibody

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  • 抗体类型:单克隆
  • 抗体来源:兔
  • 抗体应用:WB, IHC-P, ICC/IF, FC, IP
  • 特异性:Human, Mouse, Rat

产品详情

  • 产品名称
    Anti-Integrin alpha 5 Rabbit antibody
  • 抗体类型
    单克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Integrin alpha 5 Rabbit monoclonal antibody
  • 抗体应用
    WB, IHC-P, ICC/IF, FC, IP
  • 应用推荐

    1:1000-1:5000

    1:50

    1:100

    1:20-1:100

    1:20

  • 特异性
    Human, Mouse, Rat
  • 蛋白别名
    FNRA; CD49e; VLA-5; VLA5A
  • 制备方法
    Antigen: A synthetic peptide of human Integrin alpha 5
  • 组分
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • 储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • 背景介绍
    Swiss-Prot Acc.P08648.Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
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