Anti-MLH1 (4C1) Mouse antibody

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  • 抗体类型:单克隆
  • 抗体来源:小鼠
  • 抗体应用:WB, IHC-P, ICC/IF
  • 特异性:Human, Monkey

产品详情

  • 产品名称
    Anti-MLH1 (4C1) Mouse antibody
  • 抗体类型
    单克隆
  • 抗体来源
    小鼠
  • 抗体亚型
    小鼠IgG1
  • 抗体描述
    MLH1 (4C1) Mouse monoclonal antibody
  • 抗体应用
    WB, IHC-P, ICC/IF
  • 应用推荐

    WB: 1/500 - 1/2000

    IHC: 1/200 - 1/1000

    ICC: 1/200 - 1/1000

    ELISA: 1/10000

  • 特异性
    Human, Monkey
  • 制备方法
    Antigen: Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.
  • 组分
    Ascitic fluid containing 0.03% sodium azide.
  • 储存方法
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • 背景介绍
    Swiss-Prot Acc.P40692.DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a commoncharacteristic of several different types of human cancers, either due to anMMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integralpart of the protein complex responsible for mismatch repair expressed inlymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid andgall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectalcancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.

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