- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:WB, ICC/IF, FC, IP
- 特异性:Human, Mouse, Rat
产品详情
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产品名称
Anti-Rad51 Rabbit antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Rad51 Rabbit polyclonal antibody
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抗体应用
WB, ICC/IF, FC, IP
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应用推荐
WB: 1/2000-1/10000
ICC/IF: 1/200
FC: 1/20-1/100
IP: 1/20
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特异性
Human, Mouse, Rat
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蛋白别名
RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
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制备方法
Antigen: A synthetic peptide of human Rad51
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组分
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存方法
Store at -20°C. Stable for 12 months from date of receipt.
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背景介绍
Swiss-Prot Acc.Q06609.Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).