Anti-Transferrin Receptor Rabbit antibody

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  • 抗体类型:单克隆
  • 抗体来源:
  • 抗体应用:WB, ICC/IF, IP
  • 特异性:Human, Mouse

产品详情

  • 产品名称
    Anti-Transferrin Receptor Rabbit antibody
  • 抗体类型
    单克隆
  • 抗体来源
  • 抗体亚型
    兔IgG
  • 抗体描述
    Transferrin Receptor Rabbit monoclonal antibody
  • 抗体应用
    WB, ICC/IF, IP
  • 应用推荐

    WB: 1/1000

    ICC/IF: 1/20

    IP: 1/20

  • 特异性
    Human, Mouse
  • 蛋白别名
    T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
  • 制备方法
    Antigen: Recombinant protein of human Transferrin Receptor
  • 组分
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • 储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • 背景介绍
    Swiss-Prot Acc.P02786.Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
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