- 抗体类型:单克隆
- 抗体来源:兔
- 抗体应用:WB, ICC/IF, IP
- 特异性:Human, Mouse
产品详情
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产品名称
Anti-Transferrin Receptor Rabbit antibody
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抗体类型
单克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
Transferrin Receptor Rabbit monoclonal antibody
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抗体应用
WB, ICC/IF, IP
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应用推荐
WB: 1/1000
ICC/IF: 1/20
IP: 1/20
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特异性
Human, Mouse
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蛋白别名
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
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制备方法
Antigen: Recombinant protein of human Transferrin Receptor
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组分
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存方法
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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背景介绍
Swiss-Prot Acc.P02786.Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).