Anti-Transferrin/TF antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:IHC-P
  • 特异性:Mouse Transferrin / TF

产品详情

  • 产品名称
    Anti-Transferrin/TF antibody
  • 抗体类型
    多克隆
  • 抗体来源
  • 抗体亚型
    兔IgG
  • 抗体描述
    Rabbit polyclonal to Transferrin/TF
  • 抗体应用
    IHC-P
  • 应用推荐

    IHC-P: 0.1-2 μg/ml

  • 特异性
    Mouse Transferrin / TF
  • 蛋白别名
    beta-1 metal-binding globulin, DKFZp781D0156, PRO1557, PRO2086, serotransferrin, siderophilin, Transferrin, TF
  • 制备方法
    Produced in rabbits immunized with purified, recombinant Mouse Transferrin / TF (rh Transferrin / TF; Q921I1; Met1-His697). Transferrin / TF specific IgG was purified by Mouse Transferrin / TF affinity chromatography.
  • 组分
    0.2 μm filtered solution in PBS
  • 储存方法
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • 背景介绍
    Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte / pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. Transferrins are iron binding transport proteins which bind Fe3+ ion in association with the binding of an anion, usually bicarbonate. This transferrin binds only one Fe3+ ion per protein molecule. Transports iron ions from the hemolymph into the eggs during the vitellogenic stage. Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. When a transferrin loaded with iron encounters with a transferring receptor on cell surface, transferring binds to it and, as a consequence, is transported into the cell in a visicle by receptor-mediated endocytosis. The PH is reduced by hydrogen iron pumps. The lower pH causes transferrin to release its iron ions. The receptor is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. Each transferrin molecule has the ability to carry two iron ions in the ferric form.
  • 参考文献
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