- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IF, WB, IHC, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
BBS3 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
BBS3 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human brain tissue, human gliomas tissue. Positive IF detected in hTERT-RPE1 cells, MDCK cells. Positive IP detected in rat brain tissue. Positive WB detected in human brain tissue, HEK-293 cells, human testis tissue, mouse brain tissue, rat brain tissue. Observed molecular weight by Western-blot: 21 kDa
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抗体应用
ELISA, IF, WB, IHC, IP
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
ADP ribosylation factor like 6, ARL6, BBS3
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制备方法
This antibody was obtained by immunization of BBS3 recombinant protein (Accession Number: NM_032146). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
ADP-ribosylation factor-like protein 6 (ARL6), belongs to a small GTPase superfamily, is involved in membrane protein trafficking at the base of the ciliary organelle. ARL6 is also named Bardet-Biedl syndrome 3 protein, because defects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3), which is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. ARL6 can interact with many ARL6 interacting proteins and form BBSome complex with other BBS proteins including BBS1, BBS2, BBS4 and so on.
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参考文献
- Humbert MC, Weihbrecht K, Searby CC. ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting. Proceedings of the National Academy of Sciences of the United States of America. 109(48):19691-6. 2012.
- Leitch CC, Lodh S, Prieto-Echagüe V, Badano JL, Zaghloul NA. Basal body proteins regulate Notch signaling through endosomal trafficking. Journal of cell science. 127(Pt 11):2407-19. 2014.