重组小鼠BST2蛋白

小鼠

人胚胎肾细胞（HEK293）

Thr 52 - Asn 151

A DNA sequence encoding the mouse Bst2 (NP_932763.1) (Thr52-Asn151) was expressed with a polyhistidine tag at the N-terminus.

> (82.9+10.5) % as determined by SDS-PAGE.

The recombinant mouse Bst2 consists of 119 amino acids and predicts a molecular mass of 13.6 kDa.

BONE MARROW STROMAL ANTIGEN 2; DAMP-1 PROTEIN HOMOLOG; CD317; DAMP-1; TETHERIN; HM1.24 ANTIGEN; GREG; 2310015I10RIK; C87040; BST-2

Bone marrow stromal antigen 2

IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg protein as determined by the LAL method.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.