- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
CA8 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
CA8 Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue. Positive IP detected in mouse brain tissue. Positive WB detected in mouse skeletal muscle tissue, mouse brain tissue. Observed molecular weight by Western-blot: 32 kDa
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抗体应用
ELISA, WB, IHC, IP
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:500-1:5000
IHC: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
CA VIII, CA8, CALS, carbonic anhydrase VIII, CARP
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制备方法
This antibody was obtained by immunization of CA8 recombinant protein (Accession Number: BC015531). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
The CA8 (CARP) gene encodes carbonic anhydrase VIII, which is part of a family of zinc metalloenzyme. CA8 has a central carbonic anhydrase motif, but it lacks carbonic anhydrase activity due to absence of catalytic zinc coordinating residues(PMID:2121526). CARP is a novel IP3R1-binding protein, and is expressed in Purkinje cells abundantly. CA8 is co-localized with IP3R1 in Purkinje cells and it binds to IP3R1, reducing the affinity of the receptor for its ligand, IP3(PMID:12611586). Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3)(PMID:19461874).
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参考文献
- Liddelow SA, Dziegielewska KM, Ek CJ. Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach. PloS one. 8(7):e65629. 2013.