重组人CAMK1蛋白

人

大肠杆菌

Leu 2 - Leu 370

A DNA sequence encoding the human CAMK1 (NP_003647.1) (Leu 2-Leu 370) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.

> 85 % as determined by SDS-PAGE

The recombinant human CAMK1 comprises 371 amino acids and has a predicted molecular mass of 41.5 kDa. The apparent molecular mass of the protein is approximately 42 kDa in SDS-PAGE under reducing conditions as predicted.

CAMKI-ALPHA; CAM-KI; CAMKIALPHA; CAMK1; MGC120318; D6ERTD263E; MGC120317; AI505105; CAMKI

Calcium/calmodulin-dependent protein kinase I, isoform CRA_a

Calcium/calmodulin-dependent protein kinase or CaM kinases are serine/threonine-specific protein kinases that are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. CaM kinases activity can outlast the intracellular calcium transient that is needed to activate it. In neurons, this property is important for the induction of synaptic plasticity. Pharmacological inhibition of CaM kinases II blocks the induction of long-term potentiation. Upon activation, CaM kinases II phosphorylates postsynaptic glutamate receptors and changes the electrical properties of the synapse.

Supplied as sterile 50mM Tirs, 150mM NaCl, 10% glycerol, pH 7.5
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

Please contact us for more information.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.