重组恒河猴CD27蛋白

恒河猴

人胚胎肾细胞（HEK293）

Met 1 - Ile 192

A DNA sequence encoding the rhesus CD27 (XP_001104337.1) (Met1-Ile192) was expressed with the Fc region of human IgG1 at the C-terminus.

(87.6+8.4) % as determined by SDS-PAGE

Immobilized Rhesus CD27-Fc at 10 μg/ml (100 μl/well) can bind biotinylated human CD70-Fc (Cat:502332), The EC₅₀ of biotinylated human CD70-Fc (Cat:502332) is 10.9-25.3 ng/ml.

The recombinant rhesus comprises 413 amino acids and has a calculated molecular mass of 46.3 KDa.

T14; MGC20393; TP55; TNFRSF7; CD27; S152; S152.LPFS2

CD27L receptor

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

Lyophilized from sterile PBS, pH 7.4
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.