- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IF
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
-
产品名称
CDK5 antibody
-
抗体类型
多克隆
-
抗体来源
兔
-
抗体亚型
兔IgG
-
抗体描述
CDK5 Rabbit Polyclonal antibody. Positive WB detected in NIH/3T3 cells, mouse pancreas tissue. Positive IF detected in NIH/3T3 cells. Observed molecular weight by Western-blot: 33 kDa
-
抗体应用
ELISA, WB, IF
-
应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:20-1:200
-
特异性
Human,Mouse,Rat; other species not tested.
-
蛋白别名
CDK5, Cell division protein kinase 5, cyclin dependent kinase 5, PSSALRE, TPKII catalytic subunit
-
制备方法
This antibody was obtained by immunization of CDK5 recombinant protein (Accession Number: NM_004935). Purification method: Antigen affinity purified.
-
组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
储存方法
Store at -20℃. DO NOT ALIQUOT
-
背景介绍
Cyclin-dependent kinase 5 (CDK5), belongs to the cyclin-dependent kinase family, is a proline-directed serine/threonine-protein kinase that essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. CDK5 predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau.
-
参考文献
- Liu W, Zhang Y, Hao J. Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism. Journal of cellular biochemistry. 113(10):3186-96. 2012.