Centrin 1 antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, WB, IF
  • 特异性:Human; other species not tested.

产品详情

  • 产品名称
    Centrin 1 antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Centrin 1 Rabbit Polyclonal antibody. Positive IF detected in Hela cells. Positive WB detected in HL-60 cells, human heart tissue. Observed molecular weight by Western-blot: 20 kDa
  • 抗体应用
    ELISA, WB, IF
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:10-1:100

  • 特异性
    Human; other species not tested.
  • 蛋白别名
    Caltractin isoform 2, CEN1, Centrin 1, centrin, EF hand protein, CETN, CETN1
  • 制备方法
    This antibody was obtained by immunization of Centrin 1 recombinant protein (Accession Number: NM_004066). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    EF-hand type Ca2+-binding proteins consists of several family members, including Centrin-1, Centrin-2 and Centrin-3. The Centrin proteins are ubiquitously expressed cytoskeletal components that show increased expression during cell differentiation. Centrin-1 plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. Centrin-1 is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.
  • 参考文献
    • Wan Y, Yang Z, Guo J. Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell research. 22(7):1140-54. 2012.
    • Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. The EMBO journal. 32(4):597-607. 2013.
    • Zhao H, Zhu L, Zhu Y. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nature cell biology. 15(12):1434-44. 2013.
    • Zhang Y, Wang Y, Wei Y. The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly. Biochemical and biophysical research communications. 458(3):494-500. 2015.
    • Kodani A, Yu TW, Johnson JR. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. eLife. 4:. 2015.
    • Zhang C, Zhang W, Lu Y. NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1. Cell research. 26(2):239-53. 2016.
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