- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC, IF, FC, IP, WB
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
COMT antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
COMT Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, A431 cells, BxPC-3 cells. Positive IP detected in K-562 cells. Positive FC detected in HepG2 cells. Positive IHC detected in human liver tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 30 kDa
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抗体应用
ELISA, IHC, IF, FC, IP, WB
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
catechol O methyltransferase, COMT
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制备方法
This antibody was obtained by immunization of COMT recombinant protein (Accession Number: BC000419). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Catechol O-methyltransferase (COMT) is an important enzyme that catalyzes O-methylation and inactivation of metabolically active catechol-containing bioactive molecules and drugs. The mammalian COMT enzyme exists in soluble form (24-26 kDa) and membrane-bound form (28-30 kDa), which are encoded by a single gene utilizing different promoters.
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参考文献
- Saller S, Merz-Lange J, Raffael S. Norepinephrine, active norepinephrine transporter, and norepinephrine-metabolism are involved in the generation of reactive oxygen species in human ovarian granulosa cells. Endocrinology. 153(3):1472-83. 2012.
- Prunotto M, Farina A, Lane L. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Journal of proteomics. 82:193-229. 2013.
- Liu Z, Luo X, Liu L. Histone acetyltransferase p300 promotes MKL1-mediated transactivation of catechol-O-methyltransferase gene. Acta biochimica et biophysica Sinica. 45(12):1002-10. 2013.