- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC, IP, WB
- 特异性:Human,Mouse,Rat; other species not tested.
CREST antibody
产品详情
-
产品名称
CREST antibody
-
抗体类型
多克隆
-
抗体来源
兔
-
抗体亚型
兔IgG
-
抗体描述
CREST Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human brain tissue. Positive WB detected in K-562 cells, COLO 320 cells, human heart tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 55 kDa
-
抗体应用
ELISA, IHC, IP, WB
-
应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:500-1:5000
IHC: 1:20-1:200
-
特异性
Human,Mouse,Rat; other species not tested.
-
蛋白别名
CREST, KIAA0693, LP2261, SS18 like protein 1, SS18L1, SYT homolog 1
-
制备方法
This antibody was obtained by immunization of CREST recombinant protein (Accession Number: NM_015558). Purification method: Antigen affinity purified.
-
组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
储存方法
Store at -20℃. DO NOT ALIQUOT
-
背景介绍
SS18-like 1(SS18L1) is a transcriptional activator that is required for calcium-dependent dendritic growth and branching in cortical neurons. It's also a nuclear protein interacts with CREB-binding protein and expressed in the developing brain. It helps regulate neuronal morphogenesis in calcuim-dependent manner. The N-terminal domain of SS18L1 is required for suppressing transactivation in the basal state, while the C-terminal domain is required for calcium-induced transactivation. It's part of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. This complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP
-
参考文献
- <
相关服务
抗体定制服务: 纽普生物（NovoPro）提供单克隆抗体及多克隆抗体定制服务