重组食蟹猴ART4蛋白

食蟹猴

人胚胎肾细胞（HEK293）

Thr 31 - Lys 300

A DNA sequence encoding the cynomolgus ART4 (G7PJY0) (Thr31-Lys300) was expressed with a polyhistidine tag at the C-terminus.

> 95 % as determined by SDS-PAGE

The recombinant cynomolgus ART4 comprises 250 amino acids and has a calculated molecular mass of 29.1 KDa. The apparent molecular mass of it is approximately 41-46 KDa in SDS-PAGE under reducing conditions.

MONO-ADP-RIBOSYLTRANSFERASE 4; ECTO-ADP-RIBOSYLTRANSFERASE 4; ARTC4; CD297; DOK1; DO; MONO(ADP-RIBOSYL)TRANSFERASE 4; NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 4; ADP-RIBOSYLTRANSFERASE 4 (DO BLOOD GROUP); DOMBROCK BLOOD GROUP CARRIER MOLECULE; 4432404K01RIK; MONO(ADP-RIBOSYL)TRANSFERASE

NAD(P)(+)--arginine ADP-ribosyltransferase

ADP-ribosyltransferase 4 (Dombrock blood group), also known as Mono-ADP-ribosyltransferase 4(ART4), Dombrock blood group carrier molecule and CD297, is a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. ART4 could be detected on HEL cells and erythrocytes by FACS analysis while it was absent from activated monocytes, despite the presence of ART4 mRNA in these cells. ART is also known as the carrier of the Dombrock blood group alloantigens (Do) which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.