- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC, IF, WB
- 特异性:Human, Mouse; other species not tested.
产品详情
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产品名称
DNA2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
DNA2 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human cervical cancer tissue. Positive WB detected in mouse thymus tissue. Observed molecular weight by Western-blot: 127 kDa
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抗体应用
ELISA, IHC, IF, WB
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:10-1:100
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特异性
Human, Mouse; other species not tested.
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蛋白别名
DNA2, DNA2L, FLJ10063, KIAA0083
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制备方法
This antibody was obtained by immunization of Peptide (Accession Number: NM_001080449). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
DNA2(DNA replication ATP-dependent helicase/nuclease DNA2) is also named as DNA2L, KIAA0083 and belongs to the DNA2/NAM7 helicase family. This protein includes 2 domains: DNA replication nuclease and DNA replication ATP-dependent helicase. It is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability and it can interact with DNA polymerase gamma and stimulating its activity. It can also process intermediate 5' flap structures occuring in DNA replication long-patch base excision repair in mitochondria. It has 4 isoforms produced by alternative splicing. This antibody is specific to DNA2.
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参考文献
- Tsai FL, Kai M. The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining. Cell cycle (Georgetown, Tex.). 13(21):3460-4. 2014.
- Hervouet E, Claude-Taupin A, Gauthier T. The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models. BMC cancer. 15:729. 2015.