- 抗体应用:ELISA, WB, IHC, IP
- 特异性:Human, Mouse; other species not tested.
Dynamitin Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, human brain tissue. Positive IHC detected in human lymphoma tissue. Observed molecular weight by Western-blot: 50kd
ELISA, WB, IHC, IP
Human, Mouse; other species not tested.
DCTN 50, DCTN2, DCTN50, dynactin 2, dynactin 2 (p50), Dynactin subunit 2, DYNAMITIN, p50 dynamitin, RBP50
This antibody was obtained by immunization of Recombinant Protein (Accession Number: NM_001261413). Purification method: Antigen affinity purified.
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
Dynamitin is a 50 kDa protein containing a calmodulin binding domain, a putative ATPase domain and MacMARCKS-binding domain. This protein is a part of the dynactin complex believed to link the dynactin complex to membrane compartments. Its functions are tightly associated with dynein motor protein, thus extend to vesicle trafficking and membrane integrity. Dynamitin was named so because its overexpression causes dynactin complex which contains 10 subunits, to disassemble. Its N terminal 58 amino acid is for MacMARCKS binding and residues 59-83 is responsible for calmodulin binding. This antibody is is against the internal region (69-376aa) of full length p50 dynamitin.