- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB
- 特异性:human, mouse, rat; other species not tested.
产品详情
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产品名称
EGR2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
EGR2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, human kidney tissue, mouse cerebellum tissue. Observed molecular weight by Western-blot: 50kd
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抗体应用
ELISA, WB
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
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特异性
human, mouse, rat; other species not tested.
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蛋白别名
EGR2, KROX20, Zinc finger protein Krox 20, EGR 2, DKFZp686J1957
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制备方法
This antibody was obtained by immunization of EGR2 recombinant protein (Accession Number: BC035625). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Egr2 belongs to the Egr family that binds to DNA through highly conserved zinc finger domains and has a pivotal role in hindbrain development and myelination of the peripheral nervous system, development of T and/or B cells[PMID:19169262] . It has been demonstrated that Egr2 is induced early upon TCR engagement in a NFAT-dependent manner, and that overexpression of Egr2 inhibits T cell activation[PMID:23129747]. Overexpressing Egr2 shows an upregulation of E3-ligase Cbl-band reduced production of interleukin-2 (IL-2), suggesting that Egr2 is important for the maintenance of T cell tolerance by negatively regulating T cell activation[PMID: 15834410].
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参考文献
- Wang SS, Huang HY, Chen SZ. Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells. The international journal of biochemistry & cell biology. 45(8):1825-32. 2013.
- Ogawa M, Okamura T, Ishikura S. Zfat-deficiency results in a loss of CD3ζ phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection. PloS one. 8(10):e76254. 2013.
- Gökbuget D, Pereira JA, Bachofner S. The Lin28/let-7 axis is critical for myelination in the peripheral nervous system. Nature communications. 6:8584. 2015.