EGR2 antibody

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  • 抗体类型:多克隆
  • 抗体来源:
  • 抗体应用:ELISA, WB
  • 特异性:human, mouse, rat; other species not tested.

产品详情

  • 产品名称
    EGR2 antibody
  • 抗体类型
    多克隆
  • 抗体来源
  • 抗体亚型
    兔IgG
  • 抗体描述
    EGR2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, human kidney tissue, mouse cerebellum tissue. Observed molecular weight by Western-blot: 50kd
  • 抗体应用
    ELISA, WB
  • 应用推荐

    Recommended Dilution:

    WB: 1:500-1:5000

  • 特异性
    human, mouse, rat; other species not tested.
  • 蛋白别名
    EGR2, KROX20, Zinc finger protein Krox 20, EGR 2, DKFZp686J1957
  • 制备方法
    This antibody was obtained by immunization of EGR2 recombinant protein (Accession Number: BC035625). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    Egr2 belongs to the Egr family that binds to DNA through highly conserved zinc finger domains and has a pivotal role in hindbrain development and myelination of the peripheral nervous system, development of T and/or B cells[PMID:19169262] . It has been demonstrated that Egr2 is induced early upon TCR engagement in a NFAT-dependent manner, and that overexpression of Egr2 inhibits T cell activation[PMID:23129747]. Overexpressing Egr2 shows an upregulation of E3-ligase Cbl-band reduced production of interleukin-2 (IL-2), suggesting that Egr2 is important for the maintenance of T cell tolerance by negatively regulating T cell activation[PMID: 15834410].
  • 参考文献
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