- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC, IP
- 特异性:Human,Mouse,Rat,Zebrafish; other species not tested.
产品详情
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产品名称
ELAVL2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
ELAVL2 Rabbit Polyclonal antibody. Positive WB detected in mouse cerebellum tissue. Positive IP detected in mouse cerebellum tissue. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 38-45 kDa
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抗体应用
ELISA, WB, IHC, IP
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应用推荐
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:500-1:5000
IHC: 1:20-1:200
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特异性
Human,Mouse,Rat,Zebrafish; other species not tested.
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蛋白别名
ELAV like neuronal protein 1, ELAV like protein 2, ELAV2, ELAVL2, HEL N1, HELN1, Hu antigen B, HUB
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制备方法
This antibody was obtained by immunization of ELAVL2 recombinant protein (Accession Number: NM_001171197). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
The ELAV (embryonic lethal abnormal visual system) gene of D. Melanogaste is the the first identified member of a family of neuronal RNA binding proteins that is conserved in metazoans. The proteins in this family contain three RNA Recognition Motifs (RRM), with a hinge region separating the second and third RRMs and an optional non-conserved N-terminal region. The hinge includes signals essential for nuclear export and subcellular localization [PMID:9874760]. Elav is expressed specifically in the neurons and is required for the correct development and maintenance of the nervous system. ELAVL2 can binds RNA, and recognize a GAAA motif. In addition, it can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR[PMID:18715504,21695151].
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参考文献
- Parchem RJ, Moore N, Fish JL. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell reports. 12(5):760-73. 2015.