重组小鼠EFNA2蛋白

小鼠

人胚胎肾细胞（HEK293）

Met 1 - Asn 184

A DNA sequence encoding the mouse EFNA2 (NP_031935.3) without the pro peptide (Met 1-Asn 184) was expressed, with a polyhistidine tag at the C-terminus.

> 94 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized mouse EFNA2-his at 10 μg/mL (100 μl/well) can bind mouse EphA4-Fc (Cat: 501692). The EC₅₀ of mouse EphA4-Fc is 0.57 μg/mL.

The recombinant mouse EFNA2 consists of 173 amino acids and has a predicted molecular mass of 20 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNA2 is approximately 35-40 kDa due to glycosylation.

EFNA2; ELF-1; EPLG6; HEK7-L; LERK6; EPHRIN-A2; CEK7L; LERK-6; EPL6; ELF1

Ephrin-A2

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Lyophilized from sterile PBS, pH 7.4
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.