重组小鼠EFNA2蛋白

产品详情

  • 产品名称
    重组小鼠EFNA2蛋白
  • 蛋白种属
    小鼠
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 蛋白序列
    Met 1 - Asn 184
  • 克隆构建
    A DNA sequence encoding the mouse EFNA2 (NP_031935.3) without the pro peptide (Met 1-Asn 184) was expressed, with a polyhistidine tag at the C-terminus.
  • 蛋白纯度
    > 94 % as determined by SDS-PAGE
  • 蛋白活性
    1. Measured by its binding ability in a functional ELISA.
    2. Immobilized mouse EFNA2-his at 10 μg/mL (100 μl/well) can bind mouse EphA4-Fc (Cat: 501692). The EC50 of mouse EphA4-Fc is 0.57 μg/mL.
  • 分子量
    The recombinant mouse EFNA2 consists of 173 amino acids and has a predicted molecular mass of 20 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEFNA2 is approximately 35-40 kDa due to glycosylation.
  • 蛋白别名
    EFNA2; ELF-1; EPLG6; HEK7-L; LERK6; EPHRIN-A2; CEK7L; LERK-6; EPL6; ELF1
  • 蛋白全名
    Ephrin-A2
  • 蛋白描述
    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
  • 发货形式
    Lyophilized from sterile PBS, pH 7.4
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    < 1.0 EU per μg of the protein as determined by the LAL method
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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