Eribulin Monoclonal Antibody

0 条评论 | 添加你的评论
  • 抗体类型:单克隆
  • 抗体来源:
  • 抗体应用:ELISA
  • 特异性:Chemical

产品详情

  • 产品名称
    Eribulin Monoclonal Antibody
  • 抗体类型
    单克隆
  • 抗体亚型
    Mouse IgG1, κ
  • 抗体描述
    Product has been tested in direct ELISA.
  • 抗体应用
    ELISA
  • 应用推荐
    ELISA: 1:5,000-1:20,000
  • 特异性
    Chemical
  • 制备方法
    Eribulin conjugated with BSA. Protein G affinity purified
  • 组分
    PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.
  • 储存方法
    Store at -20℃. Avoid freeze / thaw cycles.
  • 背景介绍
    Eribulin is a synthetic analogue of halichondrin B which is a large polyether macrolide derived from a very strong natural mitotic tubule inhibitor. Eribulin acts by inhibiting the dynamics of the microtubules. It binds to the plus ends of the microtubules and suppresses the microtubule growth in the interphase cells without affecting the shortening phase and sequesters tubulin into nonproductive aggregates, leading to G2/M cell-cycle block and ultimately apoptosis after prolonged mitotic blockage. Its mechanism is distinct from other microtubule inhibitors like vinca alkaloids and taxanes, which affect both the shortening and growing phases.
  • 参考文献
    • Watanabe K, Yui Y, Sasagawa S, Suzuki K, Kanamori M, Yasuda T, Kimura T. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4;10(2):161-174. doi: 10.18632/oncotarget.26536. PMID: 30719211; PMCID: PMC6349434.
    • Okouneva T, Azarenko O, Wilson L, Littlefield BA, Jordan MA. Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther. 2008 Jul;7(7):2003-11. doi: 10.1158/1535-7163.MCT-08-0095. PMID: 18645010; PMCID: PMC2562299.
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！