重组人EPOR蛋白

产品详情

  • 产品名称
    重组人EPOR蛋白
  • 蛋白种属
    人
  • 表达宿主
    人胚胎肾细胞（HEK293）
  • Unitprot ID
    P19235
  • 克隆构建
    A DNA sequence encoding the extracellular domain (Met 1-Pro 250) of human erythropoietin receptor (NP_000112.1) precursor was fused with a polyhistidine tag at the C-terminus.
  • 蛋白纯度
    > 98 % as determined by SDS-PAGE
  • 蛋白活性
    Measured by its ability to inhibit EPOdependent proliferation of TF-1 human erythroleukemic cells.
    The ED50 for this effect is typically 15-60 ng/mL in the presence of 0.1 U/mL Recombinant Human EPO.
  • 分子量
    The secreted recombinant human EPOR consists of 237 amino acids and has a predicted molecular mass of 26.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhEPOR is approximately 34 kDa due to glycosylation.
  • 蛋白别名
    EPOR; EPO R; EPO-R; ERYTHROPOIETIN RECEPTOR; EPO RECEPTOR
  • 蛋白全名
    Erythropoietin receptor
  • 蛋白描述
    Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
  • 发货形式
    Lyophilized from sterile PBS, pH 7.4
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    < 1.0 EU per μg of the protein as determined by the LAL method
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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