- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
FAF1 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
FAF1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, K-562 cells, mouse brain tissue, mouse testis tissue. Positive IHC detected in human prostate cancer tissue. Observed molecular weight by Western-blot: 66-74kd
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抗体应用
ELISA, WB, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
CGI 03, FAF1, FAS assOCiated factor 1, FLJ37524, hFAF1, HFAF1s, UBXD12, UBXN3A
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制备方法
This antibody was obtained by immunization of FAF1 recombinant protein (Accession Number: NM_007051). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
FAF1 was detected most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon, but not in the peripheral blood leukocytes.The N-terminal region (amino acid 1∼201) including the upstream ubiquitin homology domain of hFAF1 could bind with the death domain of Fas, which mediates programmed cell death, also called apoptosis, in a number of organ systems, notably the immune and nervous systems.
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参考文献
- Cheng K, Bai L, Belluscio L. Fas-associated factor 1 as a regulator of olfactory axon guidance. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(33):11905-13. 2011.
- Sul JW, Park MY, Shin J. Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration. Human molecular genetics. 22(8):1558-73. 2013.
- Kim JM, Kim SS, Lee YD. Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice. Neuroreport. 26(13):767-72. 2015.