- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IF, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
FASTKD2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
FASTKD2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, mouse heart tissue, transfected cells. Positive IP detected in mouse heart tissue. Positive IF detected in COS7 cells, U2OS cells. Observed molecular weight by Western-blot: 73-75 kDa
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抗体应用
ELISA, WB, IF, IP
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:1000
IF: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
FAST kinase domains 2, FASTKD2, KIAA0971
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制备方法
This antibody was obtained by immunization of FASTKD2 recombinant protein (Accession Number: NM_001136193). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
FASTKD2(FAST kinase domain-containing protein 2) is also named as KIAA0971 and belongs to the FAST kinase family.A potential cleavage site of the 79 kDa FASTKD2 precursor protein by the mitochondrial matrix protease (MMP) is present between M52 and Q53 and predicts the mature imported protein from the FASTKD2 precursor to be composed of 642 amino acid residues for a MW of approximately 73 kDa(PMID: 18771761) and the clinical and MRI findings of the FASTKD2-associated disease are rather unusual for mitochondrial disorders.
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参考文献
- Antonicka H, Shoubridge EA. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Cell reports. 2015.
- Popow J, Alleaume AM, Curk T, Schwarzl T, Sauer S, Hentze MW. FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation. RNA (New York, N.Y.). 21(11):1873-84. 2015.
- Jourdain AA, Koppen M, Rodley CD. A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function. Cell reports. 10(7):1110-21. 2015.