- 抗体类型:单克隆
- 抗体来源:小鼠
- 抗体应用:ELISA, WB, IF, FC, IHC
- 特异性:Human; other species not tested.
产品详情
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产品名称
FKBP52 antibody
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抗体类型
单克隆
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抗体来源
小鼠
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抗体亚型
小鼠IgG
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抗体描述
FKBP52 Mouse Monoclonal antibody. Positive IF detected in HeLa cells. Positive IHC detected in human cervical cancer tissue, human colon cancer tissue. Positive FC detected in HeLa cells. Positive WB detected in HeLa cells, K-562 cells, MCF7 cells. Observed molecular weight by Western-blot: 52 kDa
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抗体应用
ELISA, WB, IF, FC, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:10-1:100
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特异性
Human; other species not tested.
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蛋白别名
51 kDa FK506 binding protein, 52 kDa FK506 binding protein, 52 kDa FKBP, 59 kDa immunophilin, FK506 binding protein 4, FK506 binding protein 4, 59kDa, FKBP 4, FKBP 52, FKBP4, FKBP51, FKBP52, FKBP59, HBI, HSP binding immunophilin, Hsp56, Immunophilin FKBP52, p52, p59, PPIase, PPIase FKBP4, Rotamase
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制备方法
This antibody was obtained by immunization of FKBP52 recombinant protein (Accession Number: NM_002014). Purification method: Protein G purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
FKBP52 (FK506 binding protein 4) is a member of the immunophilin protein family that comprises intracellular protein effectors of immunosuppressive drugs, and it is known as a steroid receptor-associated protein. As a novel regulator of microtubule dynamics, FKBP52 is associated with the motor protein dynein and with the cytoskeleton during mitosis. FKBP52 is highly expressed in CNS regions susceptible to Alzheimer's, and plays a role in modulating toxicity of Abeta peptides. The protein can associate with the Tau function, and may help to decipher and modulate the events involved in Tau-induced neurodegeneration. In addition, FKBP52 is likely to play a role in growth and development of the male genitalia.