重组人B3GAT3蛋白

人

大肠杆菌

Glu 72 - Val 335

A DNA sequence encoding the human B3GAT3 (NP_036332.2) (Glu72-Val335) was expressed with a polyhistidine tag at the N-terminus.

> 85 % as determined by SDS-PAGE

The recombinant human B3GAT3 consists of 282 amino acids and predicts a molecular mass of 31.5 KDa. It migrates as an approximately 33 KDa band in SDS-PAGE under reducing conditions.

SQV-8-LIKE PROTEIN; UDP-GLCUA:GAL BETA-1; GLCAT-I; GLCUAT-I; 3-GLUCURONYLTRANSFERASE 3 (GLUCURONOSYLTRANSFERASE I); GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3; 2810405M13RIK; 3-GAL-R GLUCURONYLTRANSFERASE; GLUCURONOSYLTRANSFERASE I; GLCATI; GLUCURONYLTRANSFERASE I; BETA-1; B3GAT3

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
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Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.