- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB
- 特异性:human, mouse, rat; other species not tested.
产品详情
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产品名称
HDAC3-specific antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
HDAC3-specific Rabbit Polyclonal antibody. Positive WB detected in HL-60 cells, human stomach tissue, U-937 cells. Observed molecular weight by Western-blot: 50kd
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抗体应用
ELISA, WB
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
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特异性
human, mouse, rat; other species not tested.
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蛋白别名
HDAC3, histone deacetylase 3, RPD3, RPD3 2, HD3
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制备方法
This antibody was obtained by immunization of Peptide (Accession Number: NM_003883). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the (-amino groups of lysines located near the amino termini of core histone proteins. At least 4 classes of HDAC were identified. HDAC3 is a class I HDAC. HDAC3 has histone deacetylase activity and may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. The gene encoding HDAC3 is regarded as a potential tumor suppressor gene. This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human HDAC3. This antibody is specific to HDAC3, and will not cross react with other HDACs.