重组甲型H1N1流感HA蛋白

甲型H1N1流感

人胚胎肾细胞（HEK293）

Met 1 - Arg 344

A DNA sequence encoding the Influenza A virus (A/Ohio/07/2009 (H1N1)) hemagglutinin (ACR38870.1) (Met1-Arg344), termed as HA1, was expressed with a C-terminal polyhistidine tag.

> 95 % as determined by SDS-PAGE

The recombinant HA1 subunit of Influenza A virus (A/Ohio/07/2009 (H1N1)) comprises 338 amino acids and has a predicted molecular mass of 37.7 kDa. The apparent molecular mass of the protein is approximately 52.9 kDa in SDS-PAGE under reducing conditions.

HAMSV; H-RASIDX; C-BAS/HAS; SPNA-1; CTLO; HA; SPNA1; C-HA-RAS1; SPH; C-H-RAS; P21RAS; AI451697; NMF4; IHJ; HRAS1; AF093576; RASH1

Hemagglutinin

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.