重组人ACVR2A蛋白

产品详情

  • 产品名称
    重组人ACVR2A蛋白
  • 蛋白种属
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 克隆构建
    A DNA sequence encoding the Human ACVR2A/ACVR2 Ala20-Pro134 is expressed with a 6His tag at the C-terminus.
  • 蛋白纯度
    >95% as determined by SDS-PAGE.
  • 蛋白别名
    ACVR2
  • 蛋白全名
    activin A receptor type 2A(ACVR2A)
  • 蛋白描述
    Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
  • 发货形式
    Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
声明:本公司出售产品只能用于科研目的,不得用于诊断或者治疗!