重组人CDK5蛋白

产品详情

  • 产品名称
    重组人CDK5蛋白
  • 蛋白种属
  • 表达宿主
    杆状病毒 - 昆虫细胞
  • Unitprot ID
  • 蛋白序列
    Met 1 - Pro 292
  • 克隆构建
    A DNA sequence encoding the human CDK5 isoform 1 (NP_004926.1) (Met 1-Pro 292) was fused with the GST tag at the N-terminus.
  • 蛋白纯度
    > 94 % as determined by SDS-PAGE
  • 蛋白活性
    No Kinase Activity
  • 分子量
    The recombinant human CDK5/GST chimera consists of 516 amino acids and has a predicted molecular mass of 59.6 kDa as estimated in SDS-PAGE under reducing conditions.
  • 蛋白别名
    CRK6; AW048668; PSSALRE; CDK5
  • 蛋白描述
    Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was joined by CDK5, which is an atypical member in that it uses its own activators and is multifunctional, playing important regulatory roles in multiple cellular functions. CDK5, unlike other Cdks, is not regulated by cyclins, and its activity is primarily detected in postmitotic neurons in developing and adult nervous systems. CDK5 is activated by association with a neuron-specific activator, p35 or its isoform p39. CDK5 is probably involved in the control of the cell cycle. It interacts with D1 and D3-type G1 cyclins. CDK5 can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. It also interacts with p35 which activates the kinase. CDK5 plays important roles in various neuronal activities, including neuronal migration, synaptic activity, and neuronal cell death.
  • 发货形式
    Lyophilized from sterile PBS, 0.5mM GSH, pH 7.0
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    < 1.0 EU per μg of the protein as determined by the LAL method
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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