重组人CHAD蛋白

人

人胚胎肾细胞（HEK293）

A DNA sequence encoding the Human CHAD/SLRR4A Cys23-His359 is expressed with a 6His tag at the C-terminus.

>95% as determined by SDS-PAGE.

SLRR4A

chondroadherin(CHAD)

Chondroadherin is a secreted protein that belongs to the small leucine-rich proteoglycan (SLRP) family of SLRP class IV subfamily. Chondroadherin contains one LRRCT domain, one LRRNT domain, and nine LRR (leucine-rich) repeats. It presents in chondrocytes at all ages. Chondroadherin is initially found as a 36-kD matrix protein isolated from bovine cartilage. It is shown to mediate chondrocyte-matrix interactions. Chondroadherin promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin α2β1. Chondroadherin may play an important role in the regulation of chondrocyte growth and proliferation.

Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

<1.0 EU per μg protein as determined by the LAL method.

Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.