- 蛋白种属:人
- 表达宿主:人胚胎肾细胞(HEK293)
- Unitprot ID:O95727
产品详情
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产品名称
重组人CRTAM蛋白
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蛋白种属
人
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表达宿主
人胚胎肾细胞(HEK293)
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Unitprot ID
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克隆构建
A DNA sequence encoding the Human CRTAM Ser18-Ser286 is expressed with a 6His tag at the C-terminus.
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蛋白纯度
>95% as determined by SDS-PAGE.
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蛋白全名
cytotoxic and regulatory T-cell molecule(CRTAM)
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蛋白描述
Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNγ or IL-22 production.
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发货形式
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
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内毒素
<1.0 EU per μg protein as determined by the LAL method.
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保存条件
Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
重组蛋白定制服务:
纽普生物(NovoPro)提供大肠杆菌、哺乳细胞、昆虫细胞和酵母细胞重组蛋白定制服务
声明:本公司出售产品只能用于科研目的,不得用于诊断或者治疗!