重组人EGFR蛋白

人

人胚胎肾细胞（HEK293）

A DNA sequence encoding the Human EGFR/ERBB/ERBB1/HER1 Leu25-Ser645 is expressed with a Fc tag at the C-terminus.

>95% as determined by SDS-PAGE.

ERBB; ERBB1; HER1

epidermal growth factor receptor(EGFR)

EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.

Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

<1.0 EU per μg protein as determined by the LAL method.

Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.