重组人IFNL3蛋白

人

人胚胎肾细胞（HEK293）

A DNA sequence encoding the Human IFNL3/IL28B/IL28C/ZCYTO22 Val22-Val196 is expressed with a 6His tag at the C-terminus.

>95% as determined by SDS-PAGE.

IL28B; IL28C; ZCYTO22

interferon lambda 3(IFNL3)

Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,1mM EDTA,pH7.4.

<1.0 EU per μg protein as determined by the LAL method.

Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.